Spindle Positioning by Cortical Pulling Forces
نویسندگان
چکیده
منابع مشابه
Spindle Positioning: Actin Mediates Pushing and Pulling
To divide asymmetrically, the mitotic spindle is moved from the cell center to the cortex, a process that requires astral microtubules and the microtubule-based motor dynein. New work examining spindle positioning in large oocytes shows that in these cells actin and actin polymerization plays a key role.
متن کاملPositioning of microtubule organizing centers by cortical pushing and pulling forces
Positioning of microtubule (MT) organizing centers with respect to the confining geometry of cells depends on pushing and/or pulling forces generated by MTs that interact with the cell cortex (Dogterom et al 2005 Curr. Opin. Cell Biol. 17 67–74). How, in living cells, these forces lead to proper positioning is still largely an open question. Recently, it was shown by in vitro experiments using ...
متن کاملForces positioning the mitotic spindle: Theories, and now experiments.
The position of the spindle determines the position of the cleavage plane, and is thus crucial for cell division. Although spindle positioning has been extensively studied, the underlying forces ultimately responsible for moving the spindle remain poorly understood. A recent pioneering study by Garzon-Coral et al. uses magnetic tweezers to perform the first direct measurements of the forces inv...
متن کاملMechanisms of spindle positioning: cortical force generators in the limelight.
Correct positioning of the spindle governs placement of the cytokinesis furrow and thus plays a crucial role in the partitioning of fate determinants and the disposition of daughter cells in a tissue. Converging evidence indicates that spindle positioning is often dictated by interactions between the plus-end of astral microtubules that emanate from the spindle poles and an evolutionary conserv...
متن کاملPulling the spindle into shape
Tilt back to turn left perating an eggbeater vertically creates a vortex, but a slight tilt makes fluid move across a bowl. now claim that a similar backward tilting of mouse cilia may create a flow that defines the left side of the embryo. Flow had already been established as a determinant of left–right asymmetry, at least in mice. Leftwards flow is created by a group of ف 30 cilia in the mo...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2005
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2005.03.014